The variety of theories explain regional development disparity – in social and economic terms-stress the need to study these theories and their application in spatial organization of the economy in a given a given place. The main elements of the spatial organization are the spatula structure, spatial interaction. The aim of applied economic geography is to understand these theories and their application in different location and regions and to select the proper theory and research approach to construct the theoretical framework of scientific work in economic geography. Following theories could be seen as examples: - Economic clusters - International trade - Networks - Industrial districts - Faradism - Flexible specialization - New faradism - Regulation Theory